次世代型VLPワクチン
研究開発センター

論文

　　　
• (1) Kuurdor EDM, Negoro M, Amexo JX, Sugata K, Tonto PB, Simbeya A, Ohtsuka J, Yamamoto S, Ogasawara N, Fukumura M, Nosaka T, Kamiya H, Taniguchi K. Temporal trends in RSV-specific antibody seroprevalence among hosptalized children during the COVID-19 pandemic in Japan: A retrospective cross-sectional study. BMC Infect Dis Mar 17, 2026 online ahead of print
　　　
• (2) Simbeya A, Negoro M, Kuurdor EDM, Sugata K, Nagao M, Ohtsuka J, Yamamoto S, Ogasawara N, Fukumura M, Nosaka T, Suga S, Taniguchi K. Trajectories and determinants of Respiratory Syncytial virus prefusion F-specific IgG in older adults. BMC Infect Dis Apr 30, 2026 online ahead of print.
　　　
• (3) Takumi-Tanimukai Y, Yamamoto S, Yoshida Y, Takahashi T, Takasawa A, Katsuyama A, Nishimaki T, Maeda H, Mizuta K, Idogawa M, Mitsuhashi Y, Takayanagi Y, Lokupathirage SMW, Yoshida K, Yamamoto K, Kakuki T, Jitsukawa S, Sato T, Sawa H, Orba Y, Sato A, Kojima T, Kamitani W, Ichikawa S, Nosaka T, Takano K, Yokota S, Ogasawara N. Sparfloxacin reveals a host-virus dual-target antiviral scaffold against respiratory syncytial virus. Commun Biol in press.
　　　
• (4) Fujimoto H, Yasuma T, D'Alessandro-Gabazza C, Toda M, Nishihama K, Takeshita A, D'Alessandro VF, Tomaru A, Saiki H, Okano T, Kogue Y, Anoh T, Alhawsawi M, Abdel-Hamid A, Imai B, Teofanovic J, Leistikow K, Ono R, Nosaka T, Yamazaki H, Yamakawa D, Bando Y, Sugihara F, Kikuta J, Kataoka K, Kondoh Y, Sakaue T, Takeda H, Yano Y, Hataji O, Cann I, Professor Kobayashi T, Fields C, Gabazza EC. Corisin induces proteostasis stress to drive epithelial injury and pulmonary fibrosis. Nat Commun in press.
　　　
• (5) Yoshida K, Yamamoto S, Ogasawara N, Taniguchi K, Nosaka T, Yokota S. Innate immune-regulated sulfated glycosaminoglycans are associated with progeny respiratory syncytial virus retention at the cell surface in immortalized cell lines. Virology　in press.
　　　
• (6) Nishimura K, Ono R, Nagaharu K, Ohya E, Tsuji T, Ikejiri M, Nakamura A, Nosaka T, Tawara I, Sugimoto Y, Ohishi K. New insights into JAK2 germline variant-driven stromal cell alterations and proinflammatory bone marrow niche remodeling in myeloproliferative neoplasms. Leukemia in press.
　　　
• (7) Kawano A, Asaka MN, Kawaqno M, Sekijima H, Sakai-Sugino K, Komada H, Yamakawa N, Horibata S, Matsuo K, O'Brien M, Nosaka T, Yasutomi Y. Development of a novel mucosal vaccine vector derived from human parainfluenza virus type 2 and its efficacy as a SARS-CoV-2 vaccine by intratracheal administration using transgenic mice expressing human angiotensin-converting enzyme 2. Genes Cells 30: e70058, 2025.
　　　
• (8) Yasuma T, Fujimoto H, D'Alessandro-Gabazza CN, Toda M, Uemura M, Nishihama K, Takeshita A, Fridman D'Alessandro V, Okano T, Okano Y, Tomaru A, Anoh T, Inoue C, Alhawsawi MAB, Abdel-Hamid AM, Leistikow K, King MR, Ono R, Nosaka T, Yamazaki H, Fields CJ, Mackie RI, Mi X, Shukla D, Arrington J, Yano Y, Hataji O, Kobayashi T, Cann I, Gabazza EC. Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging. Nat Commun 16: 7591, 2025.
　　　
• (9) Nosaka T, Ohtsuka J, Ohtsuka T, Fukumura M. Next generation RNA/protein-carrying vector with pleiotropic activity. Rev Med Virol 34: e70008, 2024.
　　　
• (10) Nakamura A, Masuya M, Shinmei M, Tawara I, Nosaka T, Ono R. Bahcc1 is critical for the aberrant epigenetic program in a mouse model of MLL-ENL-mediated leukemia. Blood Adv 8: 2193-2206, 2024.
　　　
• (11) D'Alessandro-Gabazza CN, Yasuma T, Kobayashi T, Toda M, Abdel-Hamid AM, Fujimoto H, Hataji O, Nakahara H, Takeshita A, Nishihama K, Okano T, Saiki H, Okano Y, Tomaru A, D'Alessandro VF, Shiraishi M, Mizoguchi A, Ono R, Ohtsuka J, Fukumura M, Nosaka T, Mi X, Shukla D, Kataoka K, Kondoh Y, Hirose M, Arai T, Inoue Y, Yano Y, Mackie RI, Cann I, Gabazza EC. Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis. Nat Commun 13: 1558, 2022.
　　　
• (12) Ohtsuka J, Imai M, Fukumura M, Maeda M, Eguchi A, Ono R, Maemura T, Ito M, Yamayoshi S, Kataoka Y, Kawaoka Y, Nosaka T. Non-propagative human parainfluenza virus type 2 nasal vaccine robustly protects the upper and lower airways against SARS-CoV-2. iScience 24: 103379, 2021.
　　　
• (13) Ono R, Masuya M, Inoue N, Shinmei M, Ishii S, Maegawa Y, Mahrjan BD, Katayama N, Nosaka T. Tett1 is not required for myeloid leukemogenesis by MLL-ENL in novel mouse models. PLos ONE 16: e0248425, 2021.
　　　
• (14) D'Alessandro-Gabazza CN, Kobayashi T, Yasuma T, Toda M, Kim H, Fujimoto H, Hataji O,Takeshita A, Nishihama K, Okano T, Okano Y, Nishii Y, Tomaru A, Fujiwara K, D'Alessandro VF, Abdel-Hamid AM, Ren Y, Pereira GV, Wright CL, Hernandez A, Fields CJ, Yau PM, Wang S, Mizoguchi A, Fukumura M, Ohtsuka J, Nosaka T, Kataoka K, Kondoh Y, Wu J, Kawagishi H, Yano Y, Mackie RI, Cann I, Gabazza EC. A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis. Nat Commun 11:1539, 2020.
　　　
• (15) Ohtsuka J, Fukumura M, Furuyama W, Wang S, Hara K, Maeda M, Tsurudome M, Miyamoto H, Kaito A, Tsuda N, Kataoka Y, Mizoguchi A, Takada A, Nosaka T. A versatile platform technology for recombinant vaccines using non-propagative human parainfluenza virus type 2 vector. Sci Rep 9: 12901, 2019.
　　　
• (16) Ono R, Masuya M, Ishii S, Katayama N, Nosaka T. Eya2, a target activated by Plzf, is critical for PLZF-RARA-induced leukemogenesis. Mol Cell Biol 37: e00585-16, 2017.
　　　
• (17) Ohtsuka J, Fukumura M, Tsurudome M, Hara K, Nishio M, Kawano M, Nosaka T. Vero/BC-F: an efficient packaging cell line stably expressing F protein to generate single round-infectious human parainfluenza virus type 2 vector. Gene Ther 21:775-784, 2014.
　　　
• (18) Hara K, Fukumura M, Ohtsuka J, Kawano M, Nosaka T. Human parainfluenza virus type 2 vector induces dendritic cell maturation without viral RNA replication/transcription. Hum Gene Ther 24: 683-691, 2013.
　　　
• (19) Ono R, Masuya M, Nakajima H, Enomoto Y, Miyata E, Nakamura A, Ishii S, Suzuki K, Shibata-Minoshima F, Katayama N, Kitamura T, Nosaka T. Plzf drives MLL-fusion-mediated leukemogenesis specifically in long term hematopoietic stem cells. Blood 122: 1271-1283, 2013.