ゲノム操作・解析技術開発ユニット

重点リサーチセンター

ゲノム操作・解析技術開発ユニット

Unit for Genomic Manipulation and Technology Development

活動実績

竹林慎一郎（代表者）

欧文原著（*は責任著者）
  1. （1）* Hayakawa T, Yamamoto A, Yoneda T, Hori S, Okochi N, Kagotani K, Okumura K, Takebayashi S. Reorganization of the DNA replication landscape during adipogenesis is closely linked with adipogenic gene expression. Journal of Cell Science,136, jcs260778, (2023)
  2. （2）Tsuji T, Ikuno A, Hayakawa T, Katsuzaki H, Takebayashi S, Kagotani K, Okumura K. Hexane Extract of Citrus sphaerocarpa Suppresses the Accumulation of Lipid Droplets in 3T3-L1 Adipocytes. ACS Food Science & Technology, 2, 1507-1516, (2022)
  3. （3）* Hayakawa T, Suzuki R, Kagotani K, Okumura K, Takebayashi S. Camptothecin-induced replication stress alters the DNA replication landscape detected by E/L Repli-Seq. Cytogenetic and Genome Research, 161, 437-444, (2021)
  4. （4）* Takebayashi S, Ryba T, Wimbish K, Hayakawa T, Sakaue M, Kuriya K, Takahashi S, Ogata S, Hiratani I, Okumura K, Okano M, Ogata M. The temporal order of DNA replication shaped by mammalian DNA methyltransferases. Cells, 10, 266, (2021)
  5. （5）* Miura H, Takahashi S, Shibata T, Nagao K, Obuse C, Okumura K, Ogata M, Hiratani I, Takebayashi S. Mapping replication timing domains genome wide in single mammalian cells with single-cell DNA replication sequencing (scRepli-seq). Nature Protocols, 15, 4058-4100, (2020)
  6. （6）Tanaka H, Igata T, Etoh K, Koga T, Takebayashi S, Nakao M. The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence-associated epigenomic remodeling. Aging Cell, 19, e13173, (2020)
  7. （7）Ikuno A, Akeda K, Takebayashi S, Shimaoka M, Okumura K, Sudo A. Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration. PLoS One, 14, e0222188, (2019)
  8. （8）Miura H, Takahashi S, Poonperm R, Tanigawa A, Takebayashi S, Hiratani I. Single-cell DNA replication profiling identifies spatiotemporal developmental dynamics of chromosome organization. Nature Genetics, 51, 1356-1368, (2019)
  9. （9）* Takahashi S, Miura H, Shibata T, Nagao K, Okumura K, Ogata M, Obuse C, Takebayashi S, Hiratani I. Genome-wide stability of the DNA replication program in single mammalian cells. Nature Genetics, 51, 529-540, (2019)
  10. （10）* Takebayashi S, Ogata S, Ogata M, Okumura K. Mapping mammalian replication domains using the ion torrent semiconductor sequencing platform. Bioscience, Biotechnology, and Biochemistry, 82, 2098-2100, (2018)
欧文総説
  1. (1) * Sakamoto M, Hori S, Yamamoto A, Yoneda T, Kuriya K, Takebayashi S. scRepli-Seq: A Powerful Tool to Study Replication Timing and Genome Instability. Cytogenetic and Genome Research, 162, 161-170, (2022)

橋詰令太郎（代表的教員）

欧文原著（*は責任著者）
  1. (1) Mochiki I, Okugawa Y, Hashizume R, Imai H, Ikejiri M, Ogura T, Nakatani K, Hori H. Psychological characteristics of Japanese patients and their family members receiving genetic counseling: A single-institute exploratory study. Journal of Genetic Counseling, 32, 128-139, (2023)
  2. (2) Wakita S, Hara M, Kitabatake Y, Kawatani K, Kurahashi H, Hashizume R. Experimental method for haplotype phasing across the entire length of chromosome 21 in trisomy 21 cells using a chromosome elimination technique. Journal of Human Genetics, 67, 565-572, (2022)
  3. (3) * Hashizume R, Matsuda S, Nagai M, Hirata K, Imai H, Kushima R. An unusual presentation of chordoma as a pyloric ring submucosal tumor: The first case report of a primary gastrointestinal lesion in humans. International Journal of Surgery Case Reports, 94, 107032, (2022)
  4. (4) Okamoto R, Hashizume R, Suzuki N, Ito R, Tokuhara T, Fujiwara H, Zhe Y, Ito H, Abe T, Dohi K. Serum-Induced Expression of Brain Natriuretic Peptide Contributes to Its Increase in Patients with HFpEF. International Journal of Molecular Sciences, 23, 2991, (2022)
  5. (5) Hanaki R, Toyoda H, Iwamoto S, Morimoto M, Nakato D, Ito T, Niwa K, Amano K, Hashizume R, Tawara I, Hirayama M. Donor-derived M2 macrophages attenuate GVHD after allogeneic hematopoietic stem cell transplantation. Immunity, Inflammation and Disease, 9, 1489-1499, (2021)
  6. (6) Okamoto R, Goto I, Nishimura Y, Kobayashi I, Hashizume R, Yoshida Y, Ito R, Kobayashi Y, Nishikawa M, Ali Y, Saito S, Tanaka T, Sawa Y, Ito M, Dohi K. Gap junction protein beta 4 plays an important role in cardiac function in humans, rodents, and zebrafish. PLoS One, 15, e0240129, (2020)
  7. (7) Okamoto R, Ali Y, Hashizume R, Suzuki N, Ito M. BNP as a Major Player in the Heart-Kidney Connection. International Journal of Molecular Sciences, 20, 3581, (2019)

栗谷健志（代表的教員）

欧文原著
  1. (1) Takebayashi S, Ryba T, Wimbish K, Hayakawa T, Sakaue M, Kuriya K, Takebayashi S, Ogata S, Hiratani I, Okumura K, Okano M, Ogata M. The Temporal Order of DNA Replication Shaped by Mammalian DNA Methyltransferases. Cells, 10, 266, (2021)
  2. (2) Kuriya K, Nishio M, Matsuda T, Umekawa H. Tea extract increases cell fusion via regulation of cell surface DC-STAMP. Biochemistry and Biophysics Reports, 22, 100759, (2020)
  3. (3) Kuriya K, Nishio M, Ono N, Masuda Y, Katsuzaki H, Kondo S, Sono J, Nakamura M, Umekawa H. Isolation and Characterization of Antihyperglycemic Compounds from Vigna angularis Extracts. Journal of Food Science, 84, 3172-3178, (2019)
  4. (4) Kuriya K, Nishio M, Wada S, Katsuzaki H, Nishise M, Okamoto H, Umekawa H. Antiosteoporotic Effects of Acer palmatum Extract on Osteoclastogenesis and Osteoblastogenesis. Journal of Medicinal Food, 22, 365-373, (2019)
欧文総説
  1. (1) Sakamoto M, Hori S, Yamamoto A, Yoneda T, Kuriya K, Takebayashi S. scRepli-Seq: A Powerful Tool to Study Replication Timing and Genome Instability. Cytogenetic and Genome Research, 162, 161-170, (2022)

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