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Discovery of 10-gingerol, an ingredient in ginger that inhibits osteoclasts

3 Mar 2021

Summary of our research

Bones are constantly being metabolized, and old bones are destroyed by osteoclasts, which are then replaced by osteoblasts to form new bones. Osteoporosis occurs when the activity of osteoclasts exceeds that of osteoblasts due to aging, lifestyle, and hormonal balance changes after menopause. In our previous study, we found that ginger extract inhibits osteoclast formation (Biosci Biotechnol Biochem. 2016;80:779-785.), but its specific active ingredients were unknown.

In this study, the fractions of ginger extract were analyzed using mouse osteoclast-like cells and zebrafish model of osteoporosis, and it was discovered for the first time that the active component is 10-gingerol. We also found that 10-gingerol inhibits osteoclast formation by inhibiting the activity of the transcription factor NFATC1, and that it decreases osteoclast function by inhibiting Cathepsin K activity. Since the ingredients contained in ginger, which are found in our daily life, are useful for improving osteoporosis, a condition in which osteoclasts predominate. It is expected to contribute to the extension of healthy life expectancy, one of the key issues of the Sustainable Development Goals (SDGs).

The achievement of this study was published in the online scientific journal Frontiers in Cell and Developmental Biology (Frontiers Media SA, Impact Factor 5.2) on March 3, 2021, with Dr. Liqing Zang (Assistant Professor, Graduate School of Regional Innovation Studies, Mie University) as the first author. (6:00 Central European Time (CET), 14:00 JST).

Researcher information

Photo of Liqing Zang

Liqing Zang, M.D., Ph.D.

Assistant Professor: Graduate School of Regional Innovation Studies, Mie University

Tel: +81-(0)59-231-5572 E-mail: liqing[at]med.mie-u.ac.jp

SHIMADA Yasuhito, M.D., Ph.D.

Assistant Professor: Department of Integrative Pharmacology, Mie University Graduate School of Medicine

Director: Mie University Zebrafish Drug Screening Center

2-174 Edobashi, Tsu, Mie, 514-8507, Japan

Tel: +81-(0)59-231-5411 E-mail: shimada.yasuhito[at]mie-u.ac.jp

KAGOTANI Kazuhiro, Ph.D.

Senior Manager: Tsuji Health & Beauty Science Laboratory, Mie University, Tsu, Japan

Tel: +81-(0)59-253-6333 E-mail:k.kagotani[at]tsuji-seiyu.co.jp