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Summary of our research
Chronic renal failure affects more than 10% of the total population in developed countries. The clinical progression of chronic kidney disease (CKD) eventually leads to end-stage renal failure that requires renal replacement therapy such as dialysis and kidney transplantation. The treatment of underlying disorders, including hypertension and diabetes, can only slow the fibrotic disease's progression. No effective therapy for CKD is currently available. There are currently more than 300,000 patients undergoing dialysis in Japan, the annual medical cost being about 1.6 trillion yen. Therefore, there is an imperative need to develop new therapeutic approaches for CKD. CKD progresses to renal fibrosis irrespective of the underlying disease.
This time, the research group from the Department of Diabetes and Endocrinology and the Department of Immunology from Mie University reported that human recombinant thrombomodulin suppresses CKD clinical progression. Human recombinant thrombomodulin is a drug approved to treat disseminated intravascular coagulation in Japan. This study showed that administration of human recombinant thrombomodulin suppresses renal interstitial fibrosis and glomerular sclerosis in a newly developed CKD mouse model, suggesting the potential application of human recombinant thrombomodulin for the treatment of CKD in the clinics.
The results of this research were published in journal "Kidney International" on October 14, 2020.
Researcher information
TAKESHITA Atsuro
Assistant Professor,Faculty of Medicine, Immunology
Specialized area:
Endocrinology/Immunology
Current research field:
Coagulation System, Diabetes complication
YASUMA Taro
Assistant Professor,Faculty of Medicine, Immunology
Specialized area:
Endocrinology/Immunology
Current research field:
Microbiome, Organ fibrosis, Diabetes
YANO Yutaka
Associate Professor,Endocrinology, Immunology
Specialized area:
Endocrinology and Metabolism
Current research field:
Diabetes complication, Metabolism
Esteban Gabazza
Professor in Medicine-Immunology, Faculty of Medicine
Specialized area:
Respiratory diseases, Coagulation System, Immunology
Current research field:
Microbiome, Pulmonary fibrosis, Pulmonary Cancer, Allergy