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Development of "Watermelon Young Fruit ExtractⓇ"

18 Apr 2023

Summary of our research

The research group led by Associate Professor Tomohiro Ito(Graduate School of Bioresource Sciences, Mie University) Professor Mamoru Koketsu (Faculty of Engineering, Gifu University) and Hagiwara Farms Co. (President Toshitsugu Hagihara)has isolated and purified two new phenolic glycosides, 2-caffeoyl-3-hydroxy-3-methylbutyric 4'-β-D-glucopyranosyloxy-3'-hydroxybenzylester (citrulluside H) and 2-caffeoyl-3-hydroxy-3- methylbutyric 4'-β-D-glucopyranosyloxybenzylester (citrulluside T) from young watermelon fruit, an agricultural byproduct of watermelon cultivation, and it was found that these new compounds inhibit photodermal aging and C. acnes-induced inflammation. Based on these research results, Hagiwara Farms Co., Ltd. has developed "Young watermelon fruit extract," a cosmetic material made from a by-product of cultivation for sustainable agricultural production. This product will be exhibited at CITE Japan 2023 scheduled to be held at Pacifico Yokohama from May 17 to 19, 2023. The result of this study were published in journal ''Photodermatology, Photoimmunology & Photomedicine'' (volume 37, page 386-394) on February 18, 2021, and in the online ''Natural Product Communications'' (volume 18, on December 30, 2022.

watermelon Cross section of watermelon

Researcher information


ITOH Tomohiro

Associate Professor, Graduate School of Bioresources, Mie University

Specialized area:

Food Functional Chemistry, Cosmetic Dermatology

Current research field:

Search for food ingredients that contribute to skin anti-aging and elucidation of their mechanisms of action



Professor, Faculty of Engineering, Gifu University

Specialized area:

Synthetic Organic Chemistry, Natural Products Chemistry

Current research field:

Preparation and their application of functional organic molecules



General Manager of Business Strategy Dept. , Hagihara Farm Co., Ltd.

Specialized area:

Breeding by genome analysis, Exploration and utilization of components contained in cucurbitaceae

Current research field:

Elucidation and utilization of components contained in watermelon