マイクロバイオーム研究センター

論文

• Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression.
  Inoue R, Yasuma T, Fridman D'39Alessandro V, Toda M, Ito T, Tomaru A, D'Alessandro-Gabazza CN, Tsuruga T, Okano T, Takeshita A, Nishihama K, Fujimoto H, Kobayashi T, Gabazza EC.
  Int J Mol Sci. 2023 Apr 3;24(7):6695.
• Inhibition of a Microbiota-Derived Peptide Ameliorates Established Acute Lung Injury.
  D'Alessandro VF, D'Alessandro-Gabazza CN, Yasuma T, Toda M, Takeshita A, Tomaru A, Tharavecharak S, Lasisi IO, Hess RY, Nishihama K, Fujimoto H, Kobayashi T, Cann I, Gabazza EC.
  Am J Pathol. 2023 Mar 23:S0002-9440(23)00113-X. Online ahead of print.
• Inflammation during Pregnancy Predisposes to Childhood Asthma by Altering Long Noncoding RNA Expression.
  Kobayashi T, Yasuma T, Gabazza EC.
  Am J Respir Cell Mol Biol. 2023 Jan 26. doi: 10.1165/rcmb.2023-0004ED. Online ahead of print.
• Risk factors for disease progression in fibrotic hypersensitivity pneumonitis.
  Fujimoto H, Yasuma T, D'Alessandro-Gabazza CN, Gabazza EC, Hataji O, Kobayashi T.
  Eur Respir J. 2023 Jan 27;61(1):2201706.
• Transforming Growth Factorβ1 Overexpression Is Associated with Insulin Resistance and Rapidly Progressive Kidney Fibrosis under Diabetic Conditions.
  D'Alessandro VF, Takeshita A, Yasuma T, Toda M, D'Alessandro-Gabazza CN, Okano Y, Tharavecharak S, Inoue C, Nishihama K, Fujimoto H, Kobayashi T, Yano Y, Gabazza EC.
  Int J Mol Sci. 2022 Nov 17;23(22):14265.
• Is the Urokinase Plasminogen Activator/Plasminogen Activator Inhibitor-1 Ratio a Marker of Sonographic Septations in Pleural Infection?
  Yasuma T, D'Alessandro-Gabazza CN, Kobayashi T, Gabazza EC, Fujimoto H.
  Am J Respir Crit Care Med. 2023 Apr 1;207(7):949.
• Is Helicobacter pylori infection inversely correlated with atopic, skin, and autoimmune diseases?
  Yasuma T, D'Alessandro-Gabazza CN, Fujimoto H, Kobayashi T, Imoto I, Gabazza EC.
  Allergy. 2022 Oct;77(10):3165-3166.
• Microbial Burden-associated Cytokine Storm May Explain Nonresolving Acute Respiratory Distress Syndrome in Patients with COVID-19.
  Yasuma T, D'Alessandro-Gabazza CN, Kobayashi T, Gabazza EC, Fujimoto H.
  Am J Respir Crit Care Med. 2022 Nov 1;206(9):1182-1183.
• The Need for a CYFRA 21-1 Cutoff Value to Predict Clinical Progression of IPF in Clinical Practice.
  Fujimoto H, D'Alessandro-Gabazza CN, Yasuma T, Kobayashi T, Gabazza EC.
  Am J Respir Crit Care Med. 2022 Sep 1;206(5):648-649.
• Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis.
  D'Alessandro-Gabazza CN, Yasuma T, Kobayashi T, Toda M, Abdel-Hamid AM, Fujimoto H, Hataji O, Nakahara H, Takeshita A, Nishihama K, Okano T, Saiki H, Okano Y, Tomaru A, Fridman D'Alessandro V, Shiraishi M, Mizoguchi A, Ono R, Ohtsuka J, Fukumura M, Nosaka T, Mi X, Shukla D, Kataoka K, Kondoh Y, Hirose M, Arai T, Inoue Y, Yano Y, Mackie RI, Cann I, Gabazza EC.
  Nat Commun. 2022 Mar 23;13(1):1558.
• Correlation of total serum HDL particles with a predictor of mortality risk in idiopathic pulmonary fibrosis.
  Yasuma T, D'Alessandro-Gabazza CN, Fujimoto H, Kobayashi T, Gabazza EC.
  Eur Respir J. 2022 Apr 14;59(4):2103175.
• The Fairy Chemical Imidazole-4-carboxamide Inhibits the Expression of Axl, PD-L1, and PD-L2 and Improves Response to Cisplatin in Melanoma.
  Inoue C, Yasuma T, D'Alessandro-Gabazza CN, Toda M, Fridman D'Alessandro V, Inoue R, Fujimoto H, Kobori H, Tharavecharak S, Takeshita A, Nishihama K, Okano Y, Wu J, Kobayashi T, Yano Y, Kawagishi H, Gabazza EC.
  Cells. 2022 Jan 22;11(3):374.
• Degradation of complex arabinoxylans by human colonic Bacteroidetes.
  Pereira GV, Abdel-Hamid AM, Dutta S, D'Alessandro-Gabazza CN, Wefers D, Farris JA, Bajaj S, Wawrzak Z, Atomi H, Mackie RI, Gabazza EC, Shukla D, Koropatkin NM, Cann I.
  Nat Commun. 2021 Jan 19;12(1):459.
• The Clinical Relevance of Infection and Its Treatment in Microscopic Polyangiitis With or Without Interstitial Lung Disease.
  Yasuma T, D'Alessandro-Gabazza CN, Hataji O, Kobayashi T, Gabazza EC.
  Chest. 2021 Dec;160(6):e682-e683.
• A Microbiome-Derived Peptide Induces Apoptosis of Cells from Different Tissues.
  Saiki H, Okano Y, Yasuma T, Toda M, Takeshita A, Abdel-Hamid AM, Fridman D'Alessandro V, Tsuruga T, D'Alessandro-Gabazza CN, Katayama K, Sugimoto M, Fujimoto H, Yamanaka K, Kobayashi T, Cann I, Gabazza EC.
  Cells. 2021 Oct 26;10(11):2885.
• Response of Lung Microbiota to Changes of Pulmonary Innate Immunity under Healthy Conditions.
  Yasuma T, D'Alessandro-Gabazza CN, Fujimoto H, Kobayashi T, Gabazza EC.
  Am J Respir Crit Care Med. 2022 Feb 15;205(4):477.
• Role of activation of the coagulation system in the pathogenesis of urticaria.
  Yasuma T, D'Alessandro-Gabazza CN, Kobayashi T, Morser J, Gabazza EC.
  Allergy. 2021 Oct;76(10):3243-3244.
• Protective Role of Recombinant Human Thrombomodulin in Diabetes Mellitus.
  Okano Y, Takeshita A, Yasuma T, Toda M, Nishihama K, Fridman D'Alessandro V, Inoue C, D'Alessandro-Gabazza CN, Kobayashi T, Yano Y, Gabazza EC.
  Cells. 2021 Aug 29;10(9):2237.
• The role of cigarette smoking-derived pollutants in the risk of mortality in idiopathic pulmonary fibrosis.
  Yasuma T, D'Alessandro-Gabazza CN, Hataji O, Kobayashi T, Gabazza EC.
  Eur Respir J. 2021 Sep 9;58(3):2101372.
• No Strong Evidence for Ruling Out the Role of Coagulation in Long-Term Disability after Critical Illness.
  Yasuma T, D'Alessandro-Gabazza CN, Hataji O, Kobayashi T, Gabazza EC.
  Am J Respir Crit Care Med. 2021 Sep 1;204(5):613.
• Degradation Products of Complex Arabinoxylans by Bacteroides intestinalis Enhance the Host Immune Response.
  Yasuma T, Toda M, Abdel-Hamid AM, D'Alessandro-Gabazza C, Kobayashi T, Nishihama K, D'Alessandro VF, Pereira GV, Mackie RI, Gabazza EC, Cann I.
  Microorganisms. 2021 May 22;9(6):1126.
• Degradation of complex arabinoxylans by human colonic Bacteroidetes.
  Pereira GV, Abdel-Hamid AM, Dutta S, D'Alessandro-Gabazza CN, Wefers D, Farris JA, Bajaj S, Wawrzak Z, Atomi H, Mackie RI, Gabazza EC, Shukla D, Koropatkin NM, Cann I.
  Nat Commun. 2021 Jan 19;12(1):459.
• Low-Dose of Intrapulmonary Pirfenidone Improves Human Transforming Growth Factorβ1-Driven Lung Fibrosis.
  Okano T, Kobayashi T, Yasuma T, D'Alessandro-Gabazza CN, Toda M, Fujimoto H, Nakahara H, Okano Y, Takeshita A, Nishihama K, Saiki H, Tomaru A, Fridman D'Alessandro V, Ishida S, Sugimoto H, Takei Y, Gabazza EC.
  Front Pharmacol. 2020 Nov 27;11:593620.
• De Novo T790M Mutation in an L858R Epidermal Growth Factor Receptor Mutant-Associated Lung Adenocarcinoma.
  Fujiwara T, Kobayashi T, Yasuma T, D'Alessandro-Gabazza CN, Toda M, Fujimoto H, Fujiwara K, Takeshita A, Nishihama K, Okano T, D'Alessandro VF, Takei Y, Hataji O, Gabazza EC.
  Cancers (Basel). 2020 Oct 21;12(10):3074.
• Thrombomodulin ameliorates transforming growth factor-β1-mediated chronic kidney disease via the G-protein coupled receptor 15/Akt signal pathway.
  Takeshita A, Yasuma T, Nishihama K, D'Alessandro-Gabazza CN, Toda M, Totoki T, Okano Y, Uchida A, Inoue R, Qin L, Wang S, D'Alessandro VF, Kobayashi T, Takei Y, Mizoguchi A, Yano Y, Gabazza EC.
  Kidney Int. 2020 Nov;98(5):1179-1192.
• A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis.
  D'Alessandro-Gabazza CN, Kobayashi T, Yasuma T, Toda M, Kim H, Fujimoto H, Hataji O, Takeshita A, Nishihama K, Okano T, Okano Y, Nishii Y, Tomaru A, Fujiwara K, D'Alessandro VF, Abdel-Hamid AM, Ren Y, Pereira GV, Wright CL, Hernandez A, Fields CJ, Yau PM, Wang S, Mizoguchi A, Fukumura M, Ohtsuka J, Nosaka T, Kataoka K, Kondoh Y, Wu J, Kawagishi H, Yano Y, Mackie RI, Cann I, Gabazza EC.
  Nat Commun. 2020 Mar 24;11(1):1539.
• Protein S protects against allergic bronchial asthma by modulating Th1/Th2 balance.
  Asayama K, Kobayashi T, D'Alessandro-Gabazza CN, Toda M, Yasuma T, Fujimoto H, Okano T, Saiki H, Takeshita A, Fujiwara K, Fridman D'Alessandro V, Nishihama K, Totoki T, Inoue R, Takei Y, Gabazza EC.
  Allergy. 2020 Sep;75(9):2267-2278.