マイクロバイオーム研究センター

重点リサーチセンター

マイクロバイオーム研究センター

Microbiome Research Center

活動実績

論文

  • Neutralization of Microbiota-Derived Corisin Shows Early Amelioration of Advanced Pulmonary Fibrosis.
    Furuhashi K, Fujimoto H, Toda M, D'Alessandro-Gabazza CN, Takeshita A, Nishihama K, Okano T, Saiki H, Tomaru A, Fridman D'Alessandro V, Cann I, Gabazza EC, Yasuma T, Hataji O, Kobayashi T.
    Adv Respir Med. 2026 Feb 6;94(1):9.

  • The role of the coagulation-fibrinolysis system in airway and lung remodeling.
    Fujimoto H, Gabazza EC.
    Respir Investig. 2025 Nov;63(6):1050-1059.

  • Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging.
    Yasuma T, Fujimoto H, D'Alessandro-Gabazza CN, Toda M, Uemura M, Nishihama K, Takeshita A, Fridman D'Alessandro V, Okano T, Okano Y, Tomaru A, Anoh T, Inoue C, Alhawsawi MAB, Abdel-Hamid AM, Leistikow K, King MR, Ono R, Nosaka T, Yamazaki H, Fields CJ, Mackie RI, Mi X, Shukla D, Arrington J, Yano Y, Hataji O, Kobayashi T, Cann I, Gabazza EC.
    Nat Commun. 2025 Aug 25;16(1):7591.

  • Exploratory Evaluation of Circulating Microbiota-Derived Corisin Levels in Women with Adverse Pregnancy Outcomes.
    Kato M, Nii M, Toriyabe K, Tamaishi Y, Takakura S, Magawa S, Yasuma T, D'Alessandro-Gabazza CN, Fujimoto H, Toda M, Cann I, Kobayashi T, Gabazza EC, Kondo E, Ikeda T.
    Antioxidants (Basel). 2025 May 31;14(6):670.

  • The Impact of Comorbidities on Serum IgG Levels and Exacerbation Risk in Chronic Obstructive Pulmonary Disease.
    Fujimoto H, Yasuma T, D'Alessandro-Gabazza CN, Gabazza EC, Hataji O, Kobayashi T.
    Am J Respir Crit Care Med. 2025 Jun;211(6):1100.

  • Inflammatory and Coagulation Marker Changes in PMX-DHP-Treated COVID-19 Patients.
    Tsukada A, Katagiri D, Izumi S, Terada-Hirashima J, Shimizu Y, Uemura Y, Toda M, Yasuma T, Gabazza CND, Fujimoto H, Kobayashi T, Gabazza EC, Sugiyama M, Noiri E, Abe S, Azuma A, Sugiyama H.
    Cureus. 2025 Feb 10;17(2):e78836.

  • Bleomycin-Induced Pulmonary Fibrosis in Transgenic Mice Carrying the Human MUC5B rs35705950 Variant.
    Tharavecharak S, Fujimoto H, Yasuma T, D'Alessandro-Gabazza CN, Toda M, Tomaru A, Saiki H, Uemura M, Kogue Y, Ito T, Furuhashi K, Okano T, Takeshita A, Nishihama K, Ono R, Hataji O, Nosaka T, Kobayashi T, Gabazza EC.
    Cells. 2024 Sep 11;13(18):1523.

  • Inhibiting Invariant Natural Killer T-Cell Activation: A Promising Strategy against Pulmonary Fibrosis.
    Yasuma T, Fujimoto H, D'Alessandro-Gabazza CN, Gabazza EC, Hataji O, Kobayashi T.
    Am J Respir Crit Care Med. 2024 Nov 15;210(10):1278.

  • Leveraging Microbiome Composition Variability for Precision Medicine in Idiopathic Pulmonary Fibrosis.
    Fujimoto H, D'Alessandro-Gabazza CN, Yasuma T, Gabazza EC, Hataji O, Kobayashi T.
    Am J Respir Crit Care Med. 2024 Aug 15;210(4):527-528.

  • Role of microbiota-derived corisin in coagulation activation during SARS-CoV-2 infection.
    Tsuruga T, Fujimoto H, Yasuma T, D'Alessandro-Gabazza CN, Toda M, Ito T, Tomaru A, Saiki H, Okano T, Alhawsawi MAB, Takeshita A, Nishihama K, Takei R, Kondoh Y, Cann I, Gabazza EC, Kobayashi T.
    J Thromb Haemost. 2024 Jul;22(7):1919-1935.

  • Adenine Nucleotide Translocases and Cellular Senescence in Idiopathic Pulmonary Fibrosis.
    Kobayashi T, Fujimoto H, D'Alessandro-Gabazza CN, Yasuma T, Gabazza EC.
    Am J Respir Cell Mol Biol. 2024 Mar;70(3):226.

  • Elevated plasma and bile levels of corisin, a microbiota-derived proapoptotic peptide, in patients with severe acute cholangitis.
    Nishiwaki R, Imoto I, Oka S, Yasuma T, Fujimoto H, D'Alessandro-Gabazza CN, Toda M, Kobayashi T, Osamu H, Fujibe K, Nishikawa K, Hamaguchi T, Sugimasa N, Noji M, Ito Y, Takeuchi K, Cann I, Inoue Y, Kato T, Gabazza EC.
    Gut Pathog. 2023 Nov 30;15(1):59.

  • Epoprostenol and Treprostinil: Differential Effects on Regulatory T-Cell Generation in Patients with Pulmonary Arterial Hypertension.
    Yasuma T, Fujimoto H, D'Alessandro-Gabazza CN, Gabazza EC, Hataji O, Kobayashi T.
    Am J Respir Crit Care Med. 2023 Dec 1;208(11):1248.

  • Inhibition of a Microbiota-Derived Peptide Ameliorates Established Acute Lung Injury.
    Fridman D'Alessandro V, D'Alessandro-Gabazza CN, Yasuma T, Toda M, Takeshita A, Tomaru A, Tharavecharak S, Lasisi IO, Hess RY, Nishihama K, Fujimoto H, Kobayashi T, Cann I, Gabazza EC.
    Am J Pathol. 2023 Jun;193(6):740-754.

  • Inflammation during Pregnancy Predisposes to Childhood Asthma by Altering Long Noncoding RNA Expression.
    Kobayashi T, Yasuma T, Gabazza EC.
    Am J Respir Cell Mol Biol. 2023 Jun;68(6):599-600.

  • Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression.
    Inoue R, Yasuma T, Fridman D'Alessandro V, Toda M, Ito T, Tomaru A, D'Alessandro-Gabazza CN, Tsuruga T, Okano T, Takeshita A, Nishihama K, Fujimoto H, Kobayashi T, Gabazza EC.
    Int J Mol Sci. 2023 Apr 3;24(7):6695.

  • Is the Urokinase Plasminogen Activator/Plasminogen Activator Inhibitor-1 Ratio a Marker of Sonographic Septations in Pleural Infection?
    Yasuma T, D'Alessandro-Gabazza CN, Kobayashi T, Gabazza EC, Fujimoto H.
    Am J Respir Crit Care Med. 2023 Apr 1;207(7):949.

  • Risk factors for disease progression in fibrotic hypersensitivity pneumonitis.
    Fujimoto H, Yasuma T, D'Alessandro-Gabazza CN, Gabazza EC, Hataji O, Kobayashi T.
    Eur Respir J. 2023 Jan 27;61(1):2201706.

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